Outlining Approaches to Microbiome-Focused Personalized Nutrition

9:00 am MWAS: Analyzing Sub-Genomic Variation to Find Associations Between Microbial Function & Metabolic Syndroms


• The microbiome is being leveraged to personalize nutrition today. DayTwo will discuss evidence from RCTs and real-world data demonstrating the impact of personalized nutrition on individuals with pre-Diabetes and Type 2 Diabetes.
• DayTwo has also created one of the world’s largest microbiome knowledgebases linking high-resolution metagenomics with deep phenotyping information.
• We will share some highlights from our ongoing collaboration with the Weizmann Institute on the ‘Atlas of Microbiome Associations’ as well as some insights on new discovery initiatives under way in the area of metabolic syndrome and beyond.

9:30 am Microbiome Data Driven Supplements: The Next Frontier in Product Development


• Exploring BIOHM Health’s microbiome datasets, one of the largest in the world
• Delving into how that is being leveraged to create the next generation of nutrition products
• Innovation will move from starting with ingredients, to starting with data

10:00 am Viome’s Systems Biology Platform for Modulating Human Physiology Via Microbiome & Precision Medicine


• Describe Viome’s systems biology platform that includes molecular tests of microbial and human samples, translational science, and machine learning
• Show our progress on many chronic disease models based on functional (RNAseq) and compositional microbiome studies on more than 8,000 study participants, and how we convert these findings into precision nutrition
• Highlight that this is an open platform and welcome partnerships

10:30 am Break & Networking

11:00 am Panel Discussion: Pathing The Way for Personalized Approaches to Health


This panel will provide discussion as to why the microbiome is at the center of personalized health approaches, explore some of the current challenges and look for solutions whilst looking into the future to see what innovation will be key to make personalized nutrition part of everyone’s lives.

Understanding How the Gut-Brain Axis Can Be Harnessed Through Nutritional Approaches

11:30 am Food, Mood and the Gut Microbiota


• Sharing evidence to support the impact gut microbes have on central neurochemistry and behaviour, especially in stress related disorders such as depression
• Presenting recent studies indicating patients with depression have gut microbiome dysbiosis
• Demonstrating how a diet high in grains, fibres, fish and fermented foods can alleviate symptoms for patients with depression, stress or vulnerability to these conditions

12:00 pm Gut Microbiota Modulators in Regulation of Gut-Brain Axis

  • Hariom Yadav Assistant Professor, Internal Medicine- Molecular Medicine Wake Forest School of Medicine


• Determining how gut microbiota and its metabolites are interlinked with gut-brain axis and participating aging-related disorders like Alzheimer’s disease
• How diet can influence gut-brain axis by modulating microbiota
• How probiotics and prebiotics modulates gut microbiota that impact gut-brain axis and improve aging biology

Exploring Nutritional Approaches to Targeting Metabolic & Cardiovascular Disease

12:30 pm Microbiome Data as the Bridge between Sustainable Agriculture and Functional Food

12:40 pm Lunch & Networking

1:40 pm Intestinal Microbiology Shapes Population Health: Impacts of Diet & Lifestyle Risk Exposures in Torres Strait Islander Communities

  • Kerry Ivey Research Scientist , Havard TH Chan School of Public Health


• Poor diet and lifestyle exposures are implicated in substantial global increases in the non-communicable disease burden, which is particularly marked in low-income, remote, and Indigenous communities.
• The intestinal microbiome was found to substantially modulate proinflammatory markers and cardiometabolic risk in these Torres Strait Islander populations, with differential effect modification associated with community-specific patterns of disease
• Understanding how intestinal microbiome traits influence response to disease risk exposures is critical for the development of strategies that mitigate the growing burden of cardiometabolic disease in these communities

2:10 pm The Microbes In Our Food & Their Potential to Become Health Solutions


• Solarea Bio explored and discovered microorganisms present in healthy foods
• By building a discovery platform it was possible to rapidly generate and test rationally design microbial combinations including bacteria and fungi
• These show multiple health benefits including protection against bone loss in postmenopausal mice models when acting synergistically in specific combinations

Delving Into the Regulatory Landscape of Consumer Health Products That Target the Microbiome

2:40 pm Regulatory Landscape for Probiotics in the US

  • Sibyl Swift Senior VP, Scientific & Regulatory Affairs , The Natural Products Association


• Overview of dietary supplement regulations
• How probiotics fit into that landscape
• Considerations for claims on probiotic labels

3:10 pm Advertising & Marketing Probiotics: Best Practices To Avoid Legal Challenges


• Learn best practices for making compliant advertising claims for probiotics
• The Latest FTC Enforcement trends and predictions
• How to position your company to defend against Class Actions

3:40 pm Panel Discussion: Delving into the Regulatory Landscape

  • Sibyl Swift Senior VP, Scientific & Regulatory Affairs , The Natural Products Association
  • Ivan Wasserman Managing Partner , Amin Talati Wasserman LLP
  • Gerardo Toledo CEO & Co-founder , Solarea Bioscience


This panel will facilitate conversation between regulatory experts to review the current regulatory landscape and to highlight the critical challenges that need to be overcome.

4:10 pm Break & Networking

4:30 pm New Approaches for Developing Prebiotic Oligosaccharides


• Carbohydrates are the largest dietary driver of the gut microbiota
• Diversity in natural fiber structures allows the creation of 1000’s of oligosaccharides
• Prebiotics offer an alternative strategy to modulating complicated microbial communities

5:00 pm Fine Structure Drives Gut Microbiome Responses to Fibers


• Fiber physical and chemical structure determines responses of gut microbiota
• Similar microbes respond most efficiently to a given structure across individuals
• Careful attention should be paid to sourcing fibers in microbiomefocused products

5:30 pm Understanding the Background Effects of the Food Supply


• Delving into the make-up of foods
• Recognising what we know we don’t know
• A deeper look into fibre chemistry

6:00 pm End of Conference Day Two