8:30 am Registration & Morning Coffee

Reviewing the Current Landscape of Nutritional Approaches That Modulate the Microbiome

9:00 am Diet, Microbiome and Health: Past, Present & Future

  • Cindy Davis Director, Grants & Extramural Activities, NIH

Synopsis

• What is the evidence that diet can influence the microbiome?
• How can the microbiome influence the response to dietary components?
• What is the relationship between diet, the microbiome and disease risk?

9:30 am Exploring ADM’s Clinically Documented Probiotic Formula for Migraines

Synopsis

  • Migraines affect approximately one billion people worldwide and is more prevalent than diabetes, epilepsy and asthma combined
  • In recent years there has been rapid progress in our understanding of the links between the GI microbiome and multiple neurological diagnoses, including migraine
  • In this talk we will explore the role of the GI microbiome in the pathophysiology of migraine as well as examining ADM’s innovative clinical research in this field

10:00 am Moving From Probiotics to Precision Probiotics

  • Patrick Veiga Director, Health & Microbiome Science, Danone Nutricia Research

Synopsis

  • A precision approach to probiotics is needed to address the heterogeneity inherent to probiotic strains, the hosts and their microbiome
  • Lessons learned from the current approaches in the probiotics field
  • Challenges and future steps required for the development of precision probiotics

10:30 am Speed Networking

11:30 am Outlining Ocean Spray Cranberries Interest in the Microbiome & Consumer Benefits

  • Christina Khoo Director, Scientific Affairs , Ocean Spray Cranberries

Synopsis

• Discussing the benefits of prebiotics and synergies
• Looking at how to use the microbiome to assess the health benefits of your products

12:00 pm Mining Athlete Microbiomes for Next-Generation Probiotics

12:30 pm Lunch & Networking

Lunch Harnessing Nutrition to Improve GI Health & the Immune System

1:30 pm The Role of the Gut Microbiome on Human Gastrointestinal & Immune Health

Synopsis

• The importance of the gut microbiome in human health and disease; what have we learned from human studies so far
• Evidence-base and benefits of pre- and probiotics in gastrointestinal and immune health; what is after the bifidogenic effect?
• New approaches in microbiome modulation building on the pre- & probiotics evidence base; what is already there and what is still needed to fill the gaps?

2:00 pm Gut Microbiota-targeted Dietary Fiber Intervention to Improve Intestinal Inflammation: Opportunities and Challenges

  • Vishal Singh Assistant Professor, Nutritional Physiology & Microbiome , The Pennsylvania State University

Synopsis

• Therapeutic potential of targeting gut microbiome and metabolome in inflammatory bowel disease (IBD)
• Dietary fiber(s)-based nutritional interventions to induce a beneficial
and predictable shift in gut microbiota composition: the promise and reality
• Why do patients with IBD report poor tolerance to certain dietary fibers?

2:30 pm Oral Microbial Therapy for the Management of Pediatric Respiratory Allergies

Synopsis

• Primary prevention of allergic disease has proved an elusive goal despite the dramatic increase in prevalence over the past decade
• There is increasing evidence that the airway and gut microbiome influences the development of airway and food allergies
• Probiotics are increasingly considered as a promising early life intervention to prevent the development of allergies and decrease severity of reactions

3:00 pm Afternoon Break & Networking

3:30 pm Diet-Microbiome Study Design Mastermind

Synopsis

Although an increasing number of microbiome studies collect some form of dietary data or perform diet interventions, there are no clear standards in the microbiome field for how to collect diet data or how to design a
diet-microbiome study. This session will present a variety of considerations including both practical recommendations that can be immediately incorporated into studies and aspirational recommendations that will require greater effort for implementation. Questions to be discussed include:
• How do you do a diligent study when there are so many variables you cannot control with free-living people?
• How do you weigh competing interests of time, cost, and quality when designing a microbiome study?
• Strategies to ensure compliance in your test population?
• Can studies be designed to improve detection of dietary interventions?

Effectively Targeting the Microbiome in Early Life for Optimized Health Outcomes

4:30 pm Uncovering the Role of Human-Residential Bifidobacteria Probiotics As Your Lifelong Health Partner

Synopsis

  • Understanding why only certain species of Bifidobacterium naturally present in the human gut
  • Outlining how HRB species adapt to the human gut and what are their potential role on human health
  • Highlighting the key clinical effects of HRB supplementation on human health across the lifespan

5:00 pm Continuous Improvement of Infant Formula: The Next Steps

Synopsis

• Infant formula as the original “Impossible Food” – how the progressive mirroring of breast milk components as formula ingredients will require synthetic biology.
• What ingredients are most important? The case for human lactoferrin from fermentation.
• Other formula ingredients enabled by synthetic biology

5:10 pm Baby-SHIME® Technology Platform: A Step by Step Approach for PreClinical Product Testing on the Infant Gut Microbiome

Synopsis

• Introducing Baby-SHIME®: an in vitro simulation of the infant gastrointestinal tract
• Revealing efficient pre-clinical testing in a funnel approach: delivery, efficacy, long-term modulation
• Demonstrating the impact of HMOs on gut microbiota activity and composition

5:25 pm Examining Nutrition as the Key Determinant of Age-Appropriate Microbiota Development in Infants and Children

Synopsis

• Understanding optimal microbiota development link to diverse health outcomes
• Discussing breastmilk as the gold standard for infant nutrition
• Looking beyond breastfeeding: complementary diets for maturing microbiota

5:55 pm Refreshment Break

6:15 pm Evening Workshop Discussions – Ingredient Deep Dive

Advancing the Future of Prebiotics

Emerging research has suggested that the composition and abundance of the beneficial microbes in the gut can be impacted through the addition of non-digestible prebiotic compounds. There is also now a movement towards understanding how more specific compounds such as polyphenols can positively impact the microbiota. The session will seek to define what a prebiotic is, explore
how they can be utilized to improve health and discuss future frameworks for product development. Discussion points include:

  • Learn about the emerging prebiotic ingredients
  • Learn about the state and gaps in science
  • Learn about aligning emerging science and consumer comprehension

Len Monheit, Executive Director /CEO, Global Prebiotic Association /Trust Transparency Center

Advancing the Future of Probiotics

Development of probiotic supplements that claim to promote health are being commonplace across the globe. Even with the science of probiotics being thoroughly researched there has been a number of papers that suggest that many of the commercially available strains may not elicit the positive outcomes they claim to. This session will highlight key advances in the field, tackle the limitations of probiotics and highlight future avenues of opportunity for the development of dietary supplements.

Advancing the Future of Postbiotics

With the rise of microbiome sampling technologies, increasing evidence has shown metabolites including SCFA and bacteriocins derived from the beneficial bacteria in the gut are responsible for the positive health outcomes observed. These postbiotics and how they can be harnessed to improve health are gathering research interest, so this session will explore their subsequent applications in the nutritional community.

Aubrey Levitt, CEO, Postbiotics Plus

7:15 pm End of Conference Day One