8:35 am Coffee & Networking

9:10 am Chair’s Opening Remarks

Driving Precision for Development of Effective & Personalized Nutritional Products

9:20 am Accelerating Personalization of Probiotics for Greater Optimal Health Outcomes

Synopsis

  • Gut diversity and impact within chronic conditions
  • IBS and stratifying solutions based on microflora composition and genetic potential
  • ASD and paving the way for gut-brain axis models

9:50 am Session Details to Be Announced

Synopsis

10:00 am Growth Failure & the Microbiome in Preterm Infants

  • Katherine Stumpf Assistant Professor of Pediatrics, Division of Neonatology, UTSW Medical Center

Synopsis

  • Description of the normal microbiome of preterm infants and how it is altered
  • Early data on how the microbiome differs in poorly growing preterm infants versus those with normal growth
  • Discussion of the future directions for our groups’ investigations

10:30 am Changing the Trajectory of Infant Health Through Ground breaking Discoveries

11:00 am Morning Break & Refreshments

Leveraging the Power of the Gut-Brain Axis to Develop Clinically Validated Products

11:30 am Optimizing Study Design of Probiotic & Other Microbiome Products – Avoiding Pitfalls for Study Success

  • Douglas Kalman Senior VP, Scientific & Regulatory Affairs, National Products Association

Synopsis

  • Discussion of various study designs
  • Importance of understanding your endpoints of interest
  • Staying away from diseased states or conditions

12:00 pm Causal Effect Relationship Between Stress Induced Depression in Alzheimer’s Disease (AD) Progression Through Single Bacteria Modulating Regulatory T Cell (Treg) & Th17 Cells (Th17) Immunity

Synopsis

  • The synbiotic is more consistent than the probiotic or prebiotic at promoting behavioral resilience to stress-induced psychological impairment
  • The synbiotic (and probiotic) may modify the gut microbiota populations to elicit the ileal-specific immune regulation
  • Treg/Th17 ratio in the periphery directs associates with the recruitment of peripheral immune cells to the limbic brain regions, including the hippocampus and prefrontal cortex

12:30 pm Investigating the Use of Probiotics to Support Antidepressant Treatment

Synopsis

  • Review of the gut-brain axis and the reciprocal links between the gut microbiome and neurological physiology
  • Dysbiosis and depression – Do patients with clinical depression have different microbiomes?
  • Probiotics and Depression – Can altering the microbiome with probiotics have an impact on neurological outcomes? Review of the current published data
  • Clinical trial review – Visbiome High Potency Probiotic recent randomized controlled trial as an add-on modality for the clinically depressed

1:00 pm Lunch & Networking

Understanding the Impact of Diet on Gut Health to Overcome Disease

2:00 pm The Edible Plant Microbiome & Human Health

Synopsis

  • Edible plants deliver microbes contributing to health
  • The extent of diversity is vast, representing an attractive source for new products
  • How Solarea developed a platform to harness these novel probiotics

2:30 pm Nutrition 2.0: Highly Personalized, Data-Driven & Focused on Chronic Health

  • Momo Vuyisich Co-Founder, Chief Science Officer & Head of Clinical Research, Viome Life Sciences

Synopsis

  • Viome Life Sciences has built an open access, systems biology platform for human health applications
  • We have developed a direct-to-consumer personalized nutrition application with integrated clinical research for continuous improvement
  • We will show preliminary efficacy data from our interventional trial

3:00 pm Exploring the Relationship Between Diet Diversity, Microbiota Composition & Disease to Optimize Healthy Outcomes

  • Vishal Singh Assistant Professor, Nutritional Physiology & Microbiome, The Pennsylvania State University

Synopsis

  • Investigating diet approaches to reduce the levels of starting bacterial species associated with diseases
  • Utilizing diet and probiotics to modulate microbiome composition to reduce the abundance of species that are detrimental to health
  • Discussing the potential of AI/machine learning algorithms to predict individual microbiome responses to changes in dietary patterns and nutrients

3:30 pm Chair’s Closing Remarks & Close of Summit