CONFERENCE DAY ONE
TUESDAY, NOVEMBER 12

7.30

Registration & Morning Coffee

 

 

The Impact of Diet and Nutrition on Human Microbiome and Health

Session Purpose:

As the importance of nutrition and dietary intake to decrease the risk of disease and improve overall health increases, the gut microbiome continues to emerge as a valuable source of scientific innovation for the food science community. Despite the global excitement, there are still significant scientific and commercial challenges when identifying microbes with known health benefits and translating that research into safe, effective and scalable dietary so of the future. The purpose of this opening theme will be to review the current understanding of the gut microbiome as it relates to nutrition and address the challenges that slow progress.

8.30

Diet, Microbiome and Health: Past, Present & Future

• What is the evidence that diet can influence the microbiome?
• How can the microbiome influence the response to dietary components?
• What is the relationship between diet, the microbiome and disease risk?

 

 

Cindy Davis
Director of Grants and Extramural Activities, Office of Dietary Supplements
NIH

9.00

The Gut Microbiota, Food Science, and Human Nutrition: A Timely Marriage

• Reviewing the advances that are allowing for more precise mechanistic insight between diet, microbiome and health status
• Combining preclinical models, food science and clinical studies to assess the impact of microbiome science
• Producing “microbiota-directed foods” that support efficient microbial transformation of ingredients into metabolic products that promote health

Michael Barratt
Assistant Professor, Pathology & Immunology
Washington University in St. Louis

9.30

The Gut Microbiota at the Intersection of Diet and Human Health

• Linking diet with chronic metabolic conditions including obesity, type 2 diabetes, and cardiovascular disease
• Using gut microbes to improve fundamental biological processes
• Reviewing new human and animal model studies to demonstrate the impact of diet on the microbiome to improve cardiovascular health

Tiffany Weir
Associate Professor, Food Science and Human Nutrition
Colorado State University

10.00

Panel Discussion: The Importance of Translating Microbiome Research to Shape the Future of Nutritional Product Development

Cindy Davis
Director of Grants and Extramural Activities, Office of Dietary Supplements
NIH

Tiffany Weir
Associate Professor, Food Science and Human Nutrition
Colorado State University

Michael Barratt
Assistant Professor, Pathology & Immunology
Washington University in St. Louis

10.30

Microbiome Analysis as a Tool in Developing Unique Functional Ingredients

• Analyzing the gut, oral, vaginal, and skin microbiomes of humans to identify baseline enterotypes and changes due to external influence
• Using microbiome, metagenome, and transcriptome analysis to extract additional relevant data in the clinical study setting
• Detecting alterations in the microbiome following supplementation with targeted functional probiotics (atopic dermatitis, metabolic health/weight loss)

Daniel Ramon Vidal
VP R&D, Health & Wellness
ADM

11.00

Morning Refreshments & Speed Networking

Targeting the Microbiome For GI, Metabolic & Immune Health

Session Purpose:

Due to the gut microbiome’s crucial impact on immune function, digestion and food metabolism, overall gut microbiota compositions and function have been consistently linked to the treatment and many cases, prevention, across a number of key GI, metabolic and immune health conditions. This theme will review the most recent advances of utilizing cutting-edge microbiome science to expand on the understanding of the role of the microbiome in determining GI, metabolic & immune health and insights from developing nutritional interventions within these populations.

12.00

Developing Novel Microbiome Interventions for the Management of Metabolic and GI Disease

• Identifying and classifying novel microbial strains that demonstrate health
benefits with understandable mechanisms of action
• Creating a data drive, integrated approach to product development
• Presenting positive clinical data for microbiome live synbiotics formulation in
patients with type 2 diabetes

12.30

Functional Attributes of Live Microbes

• Building a platform that combines clinical trial data, cell line testing, WGS insights and GI simulation models to develop breakthrough nutritional products
• Exploring a ‘microbe-systems’ approach with benefits in digestive health, immune function, reproductive health and gut barrier integrity
• Demonstrating new standards in pro- and prebiotic product development

Raja Dhir
CEO
Seed Inc.

13.00

Developing Butyrate Producing Probiotics to Treat Metabolic Disorders

• Reviewing the role microbial metabolites and their known biological activities
• Addressing the known MoAs of metabolites as a tool for future product development
• Isolating a SCFA producing bacterial strain to help treat metabolic disorders

Mike Janusz
Principal Scientist
Procter & Gamble

13.30

Food, Food and the Gut Microbiota

• Sharing evidence to support the impact gut microbes have on central
neurochemistry and behaviour, especially in stress related disorders such as
depression
• Presenting recent studies indicating patients with depression have gut
microbiome dysbiosis
• Demonstrating how a diet high in grains, fibres, fish and fermented foods can
alleviate symptoms for patients with depression, stress or vulnerability to
these conditions

Timothy Dinan
Medical Director
Atlanta Food Clinical Trials

14.00

Lunch & Networking

Multi-Omic & Bioinformatics: Assembling &
Analysing Microbiome Data For Translational Success

Session Purpose:

When organizations investigate the microbiome and its relationship with human health, recent breakthroughs in multi-omics technologies have become an important tool to characterize the structure and function of microbial communities in any given sample. Despite the success and availability of 16S rRNA sequencing, many organizations are now moving towards more complete tools, including shotgun metagenomics or metabolomics to provide precision level identification. The purpose of this theme will be to review the leading sequencing technologies that are used by industry and how those findings are translated into nutritional interventions of the future.

15.00

Microbiome Characterization – Standards, Sequencing and
Bioinformatics

Manoj Dadlani
CEO
CosmosID

15.15

The Essential Ingredients for Decoding the Microbiome with Metabolomics

• Improving mechanistic understanding to enhance practical use of information
• An illustration to show how metabolites broker important microbe-host
interactions
• Showing metabolomics as a tool to enrich insights into interaction associations

Kirk Beebe
Senior Director
Metabolon

15.25

A Systematic Analysis of Probiotic Content Label Claims versus Reality

• Metagenomics as a tool to determine product compliance
• Ways to increase sensitivity of detection
• Benefits of genome databases

Carmen Tartera
Research Microbiologist Center of Food Safety and Applied Nutrition
FDA

15.55

Profiling Nutrient and Bio-Functional Compounds to Support the Development of Food and Nutritional Products

Alexander Buko
VP, Pre-Clinical and Clinical R&D
Human Metabolome Technologies

16.05

Afternoon Refreshments & Networking

16.30

New Tools for Understanding Microbiome Spatiotemporal Ecology in Human Health and Nutrition

• Human microbiome samples show significant spatial variability; new methodology can decompose temporal, spatial and technical contributions
• New tools for characterizing microscopic spatial metagenomic distributions of bacteria (MaP-seq) reveal significant spatial structuring in mouse and human microbiome samples
• Applying these tools to understand nutritional perturbations in the mammalian gut

Ravi Sheth
Graduate Student and Researcher
Columbia University

Using Clinical Evidence To Support Microbiome Research In Nutrition

Session Purpose:

Microbiome-targeted solutions in nutrition are being actively investigated in clinical trials to further demonstrate the functional benefits of microbes across a variety of potential mechanisms. The purpose of this theme will be to review the importance of gathering clinical evidence, effective study design and examples of past and current clinical trials that are testing microbiome-targeted nutritional solutions for the treatment of a range of conditions.

17.00

Rethinking Diet to Complement Gut Microbiota Function

• Overall diet analysis - Diet – gut microbiota analysis from clinical trial reveals functional and strain association with food categories and clinical data
• Case of consumption of multi-strain fermented milk product consumption on human gut microbiota using shotgun metagenomic – Learnings
• Towards precision nutrition: selection of strains - ingredients based on nutritional use of intestinal commensal bacteria of interest

Muriel Derrien
Senior Gut Microbiota Scientist
Danone Nutricia Research

17.30

Comfort Break

Using Clinical Evidence To Support Microbiome Research In Nutrition

Session Purpose:

Designed to be more informal and interactive, the purpose of the afternoon workshop discussions will be to open a debate
around the current challenges and future perspectives of dietary components that look to target modulate the human
microbiome for improved health outcomes.

17.45     Workshop A:

Advancing the Future of Probiotics

17.45     Workshop B:

Advancing the Future of Prebiotics

17.45     Workshop C:

Advancing the Future of Postbiotics

Session Purpose:

Development of probiotic supplements that claim to promote health and wellbeing continues to increase
worldwide. Although the benefits of probiotics have been well studied, the scientific community have published a
number of clinical investigations that throw doubt on many commercially available strains and formulations.
Given the recent rise of microbiome science and technology, the purpose of this workshop session will be to highlight
the key advances, challenges and limitations of probiotic supplements and highlight the future use of this
dietary component.

Discussion Points:
• Probiotics 2.0 – moving into new indications
• Reviewing clinical and mechanistic
study design challenges
• Novel formulations and delivery
systems for novel probiotics
• Regulatory concerns and future
perspectives

Session Purpose:

Emerging research has suggested that the composition and function of host gut microbiota can be impacted through consumption of non-digestible prebiotic compounds. The purpose of this workshop will be to review the
definition of prebiotic compounds with demonstrated health benefits and develop future frameworks for product development.

Discussion Points:
• Reviewing criteria that classifies prebiotics ingredients
• New sources for prebiotic innovation
• Discussing challenges with production and commercialization
• Considering future directions and applications to improve gut health

Session Purpose:

Although the benefits of probiotics have been long established, the underlying mechanisms have often remained obscure. With the rise of metabolomics, increasing evidence has supported that bacteria-derived products, termed postbiotics and include compounds such as SCFAs,
bacteriocins and other secreted proteins have demonstrated a similar role in maintaining health of the host. The purpose of this workshop will be to review the current understanding of postbiotics and their subsequent applications to the food, nutrition and nutraceutical community.

Discussion Points:
• Overview of well-studied postbiotic ingredients
• Discussing pathways and health benefits
• Reviewing the key applications as future functional foods or
nutraceuticals

18.30

Close of Conference Day One & Evening Drinks Receptions Hosted by the Microbiome Movement