November 15-16

Boston, MA

 

Day One
Wednesday, November 15 2017

Day Two
Thursday, November 16 2017

08.00
Coffee and Registration

08.50
Chair’s Opening Remarks

CLINICAL DEVELOPMENT- VALIDATING PRODUCTS TO MAXIMISE SAFETY, EFFICACY & QUALITY

Synopsis

Introduction and Purpose:
A critical stage in the successful development of a nutritional intervention lies in the clinical research used to substantiate health claims and define regulatory requirements prior to commercialization. The purpose of this theme will be to overcome the consistent challenges faced by industry when undergoing clinical development for a microbiome-based intervention.

MORNING SESSION THEMES

09.00
A Gut Punch to Traditional Healthcare: How Nutrition-Based Solutions Will Change How We Address Diseases

Synopsis

  • Addressing GI-related health conditions through naturally-derived, broad-based solutions that are game-changing, effective and safe.
  • Developing approaches to harness the power of “nature’s first passive immunity” to re-establish immune function, reduce inflammation and reset the microbiome.

09.30
The Role of Spore-Based Probiotics in Reducing Metabolic Endotoxemia and Associated Chronic Disease Risk

Synopsis

• Outlining the rise of spore-based probiotic strains in the market
• Demonstrating through human study how spore-based strains can modulate the GI tract to reduce
metabolic endotoxemia
• Exploring research to show the potential of a probiotic to protect the host from associated chronic
disease risk

10.00
How New Insights in Mode of Action Fuel Probiotic Research

Synopsis

  • How mode of action studies on the well-documented probiotic strain Lactobacillus rhamnosus LGG® help us understand clinical benefits
  • Key examples of clinical benefits of LGG®
  • How specific components of LGG® interact in the GI tract to influence mucus adhesion, gut barrier function, and immune modulation

10.30
Morning Refreshments & Networking

PRE- AND PRO-BIOTICS: CASE STUDIES THAT EXPAND CURRENT DEFINITIONS AND PROPOSE AN ALTERNATIVE WAY FORWARD

Synopsis

Introduction and Purpose:
As R&D into the role of pre- and pro-biotics expands exponentially, do the industry need to review current
definitions when exploring product development? The purpose of this theme will be to provide an alternative to
the status-quo.

11.00
Dietary Fiber, Prebiotics and Anti-Adhesive Oligosaccharides

Synopsis

• Classical definitions and a new definition to expand the scope of prebiotics.
• Emerging prebiotics that doesn’t fit the classical definition but has direct and indirect effects on bacterial infections as well as the microbiome.
• The influence of dietary oligosaccharides on pathogen and probiotic bacterial adhesion to epithelial cells.

11.30
Probiotics: Gaps in Current Practices, and a Case for Postbiotics

Synopsis

• Classical definitions and a new definition to expand the scope of probiotics by accounting for efficacy and beneficial commensal bacteria
• Insights into formulation and labelling practices in the commercial prebiotic and probiotic functional beverage segment
• A case for Postbiotics using Kombucha as an example

12.00
The Unaddressed Role of Fungi in Probiotics as it relates to Overall Health and Wellness

DEFINING REGULATORY FRAMEWORKS- SUBSTANTIATING CLAIMS IN THE US AND EUROPE TO ACCELERATE PRODUCT DEVELOPMENT

Synopsis

Introduction and Purpose:
Current regulatory guidance of live biotherapeutics forms the basis of a strategy food companies developing nutritional solutions. With ambiguous definitions and standardisation methods, this theme will help give industry the information they need to accelerate product development.

12.30
Panel Presentation: Aligning Regulation, Science and Industry For a Clear Path to Market

Synopsis

  • Discussing current regulatory frameworks that are being used based on scientific principles, industry know-how and consumer needs
  • Importance of omics techniques to elucidate functionality and guide design of probiotic interventions
  • Targeting populations that clarify results and substantiate claims

IMPROVING EDUCATION FOR CONSUMERS- GIVING THE RIGHT INFORMATION TO MAKE HEALTHIER DECISIONS

Synopsis

Introduction and Purpose:
With infinite information, consumers are looking for choice when it comes to nutritional solutions. The purpose of this theme will be to highlight how food companies can best educate consumers in a meaningful and transparent way.

13.00
Probiotics: Communicating with the Consumer, from Clinical to Quirky

Synopsis

  • How your voice needs to match your brand personality
  • Avoiding adding to the consumer confusion
  • We may find science exciting, not everybody does

13.30
Lunch & Networking

FORMULATION METHODS TO MAINTAIN STABILITY AND INCREASE VALIDITY

Synopsis

Introduction and Purpose:
As formulation parameters can vary (liquid, lyophilized powder, encapsulated), the designated strategy to maximise stability and minimize manufacturing costs is an important consideration for a successful product. The purpose of this theme will be to review the current formulations used in industry and how this has benefited microbiome development.

14.30
Panel Discussion: Formulating with Probiotics: Selecting Strains for Stability

Synopsis

  • Discussing what traits companies look for when selecting strains for probiotic applications
  • Overcoming the main challenges when delivering the most applicable strain with substantiated health benefits
  • Outlining a framework that builds on clinical research and where current science is incomplete

INGREDIENTS BEYOND THE GUT: ACCESS TO THE GUT-BRAIN AXIS

Synopsis

Introduction and Purpose:
Strong evidence now exists that shows the complex link between gut microbiota and brain function and behaviour. The purpose of this theme will be to highlight the way companies are developing novel nutritional strategies to treat psychiatric disorders by targeting the gut microbiota.

15.00
Food for Thought: The Emerging Role of Nutrition in the Microbiota-Gut–Brain Axis

15.30
Prebiotics Impact the Gut Microbiome and Brain of Developing Animals: Evidence for Effects on the Gut-Brain Axis

Synopsis

  • Discussing how gut microbiota directly or indirectly influences the communication between the brain and the gut through various interconnected systems
  • Modulating gastrointestinal bacteria can result in demonstrable changes in brain development, neurotransmitter systems, and expression of anxiety-like behaviour
  • Outlining a study to determine the impact of polydextrose (PDX) and galactooligosaccharides (GOS), during early postnatal development on cognition, social, and anxiety-related behaviors, and gut microbiota in rodents

16.00
Chairman’s Closing Remarks

16.10
End of Inaugural Microbiome Human Nutrition Summit 2017