November 15-16

Boston, MA

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Day One
Wednesday, November 15 2017

Day Two
Thursday, November 16 2017

08.00
Coffee and Registration

08.50
Chair’s Opening Remarks

DISRUPTIVE INNOVATION- ESTABLISHING CAUSE AND EFFECT IN THE MICROBIOME

Synopsis

Introduction and Purpose:
One of the biggest concerns in the development of microbiome-based products is outlining causation vs correlation. Modern literature to date has been dominated with associative studies and not links that are causal for disease. The purpose of this theme will be to outline why the microbiome will be important for nutrition in the modern day and why this has become the case.

09.00
The Microbiome, Nutrition and Human Biology

Synopsis

  • How the human microbiome has reshaped the paradigm of biology and diet
  • Processing new insights to investigate how beneficial microbes mediate digestion and prevent disease
  • Describing how a new generation of sequencing technology coupled with new software capabilities and animal model data can lead to new translational discoveries in the human microbiome

09.30
More than a Crap Shoot…Placing Bets on Enteric Health for Healthy Growth & Development in the Developing World

  • Chris Damman MD, Program Officer, Bill and Melinda Gates Foundation

Synopsis

  • Understanding the four domains of gut dysfunction will help refine our approach to interventions that address poor growth and development in the developing world.
  • In a simplistic model, the four interdependent domains of gut health are the microbiome, epithelium (barrier function and absorption), immune system (innate and adaptive), and
    metabolism.

We hypothesize that the most effective preventative measures and therapies will need to address multiple gut health domains simultaneously, and that nutritional interventions are particularly well poised for this purpose.

APPLYING SYSTEMS BIOLOGY TO OPEN NEW DOORS FOR MICROBIOME-LEVERAGING GI INTERVENTIONS

Synopsis

Introduction and Purpose:
The design of new preventative measures and treatments will be accelerated through an integrated approach
incorporating knowledge of host nutrition, GI biology, microbial constituents and intersecting metabolic pathways.
The purpose of this theme will be to highlight the value of this methodology for identifying novel strategies and
advancing product development.

10.00
Novel Nutritional Interventions for Human Health: Exploiting New Learnings in Gut Ecosystem Biology

  • Paul Giannasca Global Scientific Lead- GI Health, Nestle Health Science

Synopsis

  • Advancing nutritional interventions as therapeutics
  • Mining bacterial culture collections for beneficial strains
  • Manipulating the gut-brain axis with probiotic bacteria

10.30
Designed Microbiome Therapies Targeting the Microbes and Beyond

Synopsis

  • Learning how gut microbiome plays an essential role in disease regulation and efficacy of therapies
  • Distinguishing a clear understanding whether dysbiosis is a cause or a consequence of the diseases and exploring the equilibrium between the gut barrier and the immune system
  • Discussing the importance of multiple-target drug cocktails comprising commensal bacteria with particular focus on successful products that treat Irritable Bowel Syndrome (IBS) and Clostridium Difficile Infection

11.00
Morning Refreshments and Speed Networking

CONTROLLING THE GUT THROUGH DIETARY MODIFICATIONS

Synopsis

Introduction and Purpose:
With infinite information, consumers are looking for choice when it comes to nutritional solutions. The purpose of this theme will be to highlight how food companies can best educate consumers in a meaningful and transparent way.

12.00
Rethinking Diet to Aid Human–Microbe Symbiosis

  • Patrick Veiga Head of the Microbes and Foods for Health Team, Danone Nutricia Research

Synopsis

  • Gut Microbiota in 3D: Dysbiosis, Disease and Diet
  • Outlining dietary changes during the course of human evolution and the recent move towards replenishing gut microbiota with missing functions
  • Tackling the variability in microbiota response to dietary interventions and the use of big data to accurately tailor nutrition plans

12.30
Microbiome Community Structure and Prediction of Response to Nutritional Therapy in Pediatric Crohn’s Disease

Synopsis

  • Understanding how dietary interventions can change microbial ecology associated with active Crohn’s disease
  • Using 16S sequencing data, our research suggests Crohn’s disease is impacted by microbiota diversity and community structure
  • Using diet to increase microbiome diversity will enable stratification of patients early on in disease course

13.00
Gut Microbial Metabolism of Dietary Constituents: Whose Diet Is It Anyway?

Synopsis

  • Gut microbes modify a variety of dietary constituents to bioactive compounds not found in the diet.
  • Components of diet can alter gut microbiome composition and activity by serving as substrates or as antimicrobials.
  • The gut microbiome should be considered in context of host diet to understand its impact on health and disease risk.

13.30
Lunch and Networking

PERSONALIZED NUTRITION- STRATIFYING POPULATIONS TO GUIDE CONSUMER PREFERENCES

Synopsis

Introduction and Purpose:
Studies have demonstrated that an in-depth knowledge of the gut microbiome can be utilised to design personalized, healthy diet plans that have beneficial effects on glucose homeostasis and help prevent against metabolic disease. The purpose of this theme will be to share the latest advances in this emerging field.

14.30
Machine Learning in the Microbiome: Providing Predictable Personalized Nutrition based on Your Gut

Synopsis

  • Developing and commercializing an algorithm that predicts blood sugar responses based on the unique diversity of the gut microbiome
  • Outlining an effective strategy to reduce blood sugar levels for individuals in the USA
  • Creating new insights to address and treat metabolic disorders through microbiome-based diagnostics/therapeutics

THE INFANT MICROBIOME: IMPLICATIONS FOR INFANT HEALTH AND NUTRITION

Synopsis

Introduction and Purpose:
Human milk oligosaccharides constitute an important class of molecules in breast milk that influences the microbial landscape of the infant’s gut. The purpose of this theme will be to show how HMO’s are currently optimizing infant health and the methods currently employed to maximize the health benefit towards the gastrointestinal microbiota.

15.00
From Dysbiosis to Recovery in the Infant Gut Microbiome: A New Paradigm in Infant Nutrition

Synopsis

  • The natural infant gut microbiome is defined by the HMOs in breast milk and is dominated by a single species – B. infantis – originating in the mother’s gut microbiome.
  • This keystone commensal organism has been generationally lost in the developed world through the unintended consequences of modern medical practices.
  • Evolve has demonstrated that this natural infant gut microbiome can be re-established and has launched the first gut microbiome remodeling product of its kind.

15.30
Afternoon Refreshments and Networking

16.00
Non-invasive Methods for Assessing Nutritional Regulation of Neonatal Gut Gene Expression and Host-Microbe Interactions in the Human Infant

  • Marcia Monaco Research Assistant Professor, Food Science and Human Nutrition, University of Illinois

Synopsis

  • Gaining insight into normal gut development and responses to where nutrition has been limited by ethical constraints on invasive sampling
  • Outlining a non-invasive sample collection to evaluate the impact of nutritional, gestational age and potentially other environmental exposures on the developing intestinal ecosystem
  • Using a systems biology and computational modeling approaches that integrates information from the host and the microbiome and that can identify important mechanistic pathways

16.30
Human Milk Oligosaccharides (HMOs) Nature’s Prebiotics for a Healthy Infant Microbiome

Synopsis

• More than 100 years ago the Human Milk Oligosaccharides (HMOs) research laid the foundation of our current view of Pre- and Probiotics
• HMOs selectively promote the growth of “beneficial” bacteria ( i.e. promotes a healthy microbiome) in infants
• HMOs are finally available for food and medical applications, in particular for Infant formula application

16.45
What’s Normal? The Human Milk Microbiome – a Paradigm Shift in Infant Nutrition

Synopsis

  • Breastfeeding is the gold standard for infant nutrition around the globe and has long been known to promote a different neonatal gastrointestinal microbiome compared to formula feeding.
  • Human milk, once thought to be sterile, actually serves as a rich and diverse source of microbes to breastfeeding infants – likely being a key and direct driver of gastrointestinal microbial colonization.
  • Emerging research suggests that there is likely no one-size-fits-all construct in terms of the human milk microbiome (or human milk composition, for that matter), and it is possible that its plasticity is driven by both evolutionary selection and environmental, social, and behavioral factors

17.15
Chairman’s Closing Remarks

17.25
End of Conference Day 1